Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12213)
Official Symbol		MIER1
Official Full Name		MIER1 Transcriptional Regulator
Synonym		MIER1 Transcriptional Regulator;KIAA1610;MI-ER1;Mesoderm Induction Early Response 1, Transcriptional Regulator;Mesoderm Induction Early Response Protein 1;HMI-ER1;HMi-Er1;Mi-Er1;Mesoderm Induction Early Response 1 Homolog;Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis)
Molecule Type		Protein coding
Position On Chromosome		chr1(Start:66924895 - End:66988619)
Strand		+
Uniprot Entry		Q8N108
ENSG ID		ENSG00000198160
Disease Relevance (Click to Show/Hide)
2C30: Melanoma of skin		Cutaneous Melanoma [Melanoma of skin]
Detailed Information		Disease Link click to show the detail information of this Disease
6B01: Panic disorder		Panic Disorder [Panic disorder]
Detailed Information		Disease Link click to show the detail information of this Disease
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate MIER1 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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