Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12197)
Official Symbol		LYSMD1
Official Full Name		LysM Domain Containing 1
Synonym		LysM Domain Containing 1;SB145;LysM And Putative Peptidoglycan-Binding Domain-Containing Protein 1;LysM, Putative Peptidoglycan-Binding, Domain Containing 1;MGC35223;RP11-68I18.5
Molecule Type		Protein coding
Position On Chromosome		chr1(Start:151148496 - End:151165948)
Strand		-
Uniprot Entry		Q96S90
ENSG ID		ENSG00000163155
Disease Relevance (Click to Show/Hide)
2C30: Melanoma of skin		Cutaneous Melanoma [Melanoma of skin]
Detailed Information		Disease Link click to show the detail information of this Disease
8A00: Parkinsonism		Parkinson's disease (PD) [Parkinsonism]
Detailed Information		Disease Link click to show the detail information of this Disease
ZERO(Not Found): Constitutional MLH1 epimutations		Constitutional MLH1 epimutations [Constitutional MLH1 epimutations]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate LYSMD1 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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