Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12195)
Official Symbol		LRRC67
Official Full Name		Protein Phosphatase 1 Regulatory Subunit 42
Synonym		Protein Phosphatase 1 Regulatory Subunit 42;LRRC67;TLLR;Dtr;TLRR;Protein Phosphatase 1, Regulatory Subunit 42;Testis Leucine-Rich Repeat;Leucine Rich Repeat Containing 67;Leucine-Rich Repeat-Containing Protein 67
Molecule Type		Protein coding
Position On Chromosome		chr8(Start:66964099 - End:67056604)
Strand		-
Uniprot Entry		Q7Z4L9
ENSG ID		ENSG00000178125
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
QA46: Outcome of delivery		Fetal intolerance of labor [Outcome of delivery]
Detailed Information		Disease Link click to show the detail information of this Disease
SE30: Developmental delay disorder		CHARGE and Kabuki syndromes [Developmental delay disorder]
Detailed Information		Disease Link click to show the detail information of this Disease
XH5QN3: Nephroblastoma		Wilms tumor [Nephroblastoma]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate LRRC67 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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