Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12149)
  Official Symbol
ISG20L2
  Official Full Name
Interferon Stimulated Exonuclease Gene 20 Like 2
  Synonym
Interferon Stimulated Exonuclease Gene 20 Like 2;FLJ12671;Interferon Stimulated Exonuclease Gene 20kDa Like 2;EC 3.1;HSD38
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:156721891 - End:156728766)
  Strand
-
  Uniprot Entry
Q9H9L3 
  ENSG ID
ENSG00000143319 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate ISG20L2 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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