Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12087)
  Official Symbol
GNAI3
  Official Full Name
G Protein Subunit Alpha I3
  Synonym
G Protein Subunit Alpha I3;87U6;Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 3;Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-3;Guanine Nucleotide-Binding Protein G(K) Subunit Alpha;HG1A;ARCND1
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:109548615 - End:109600195)
  Strand
+
  Uniprot Entry
P08754 
  ENSG ID
ENSG00000065135 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         9B75: Macular disorders Age-related macular degeneration (AMD) [Macular disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate GNAI3 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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