Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12075)
  Official Symbol
GANC
  Official Full Name
Glucosidase Alpha, Neutral C
  Synonym
Glucosidase Alpha, Neutral C;Neutral Alpha-Glucosidase C;Glucosidase, Alpha; Neutral C;EC 3.2.1.20;EC 3.2.1
  Molecule Type
Protein coding
  Position On Chromosome
chr15(Start:42273201 - End:42353666)
  Strand
+
  Uniprot Entry
Q8TET4 
  ENSG ID
ENSG00000214013 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate GANC CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.