Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12002)
  Official Symbol
COX6B1
  Official Full Name
Cytochrome C Oxidase Subunit 6B1
  Synonym
Cytochrome C Oxidase Subunit 6B1;COX6B;COXG;Cytochrome C Oxidase Subunit VIb Polypeptide 1 (Ubiquitous);COX VIb-1;MC4DN7;COXVIb1;Cytochrome C Oxidase Subunit Vib;Cytochrome C Oxidase Subunit VIb Isoform 1;Cytochrome C Oxidase Subunit Vib Polypeptide 1 (Ubiquitous)
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:35648323 - End:35658782)
  Strand
+
  Uniprot Entry
P14854 
  ENSG ID
ENSG00000126267 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate COX6B1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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