Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11972)
  Official Symbol
CCNL1
  Official Full Name
Cyclin L1
  Synonym
Cyclin L1;Cyclin L Ania-6a;Cyclin-L1;Ania-6a;Cyclin-L;BM-001
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:157143121 - End:157160760)
  Strand
-
  Uniprot Entry
Q9UK58 
  ENSG ID
ENSG00000163660 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Glomerular diseases IgA nephropathy [Glomerular diseases]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate CCNL1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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