Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11861)
  Official Symbol
PHYKPL
  Official Full Name
5-Phosphohydroxy-L-Lysine Phospho-Lyase
  Synonym
5-Phosphohydroxy-L-Lysine Phospho-Lyase;AGXT2L2;Alanine--Glyoxylate Aminotransferase 2-Like 2;5-Phosphonooxy-L-Lysine Phospho-Lyase;MGC15875;Alanine-Glyoxylate Aminotransferase 2-Like 2
  Molecule Type
Protein coding
  Position On Chromosome
chr5(Start:178207144 - End:178232822)
  Strand
-
  Uniprot Entry
Q8IUZ5 
  ENSG ID
ENSG00000175309 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate AGXT2L2 CpG site in breast cancer cells.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host AGXT2L2 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.