Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11847)
  Official Symbol
ABCB7
  Official Full Name
ATP Binding Cassette Subfamily B Member 7
  Synonym
EST140535;Atm1p;ASAT;ABC7;ATP-Binding Cassette Sub-Family B Member 7, Mitochondrial;ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7;Iron-Sulfur Clusters Transporter ABCB7, Mitochondrial;ATP-Binding Cassette Transporter 7;ABC Transporter 7 Protein;EC 3.6.3.42;EC 3.6.3
  Molecule Type
Protein coding
  Position On Chromosome
chrX(Start:75051048 - End:75156732)
  Strand
-
  Uniprot Entry
O75027 
  ENSG ID
ENSG00000131269 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Sex chromosome anomalies X-chromosome inactivation (XCI) [Sex chromosome anomalies]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate ABCB7 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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