Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11247)
  Official Symbol
MTHFR
  Official Full Name
methylenetetrahydrofolate reductase
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:11785723 - End:11806455)
  Strand
-
  Uniprot Entry
L7P8G6 
  ENSG ID
ENSG00000177000 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Riboflavin (B2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
RIboflavin (B2) has been shown the MTHFR north shore was significantly hypomethylated ( 1.24% +/- 0.50% vs.0.90% +/- 0.50%

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.

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