Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM05729)
  Official Symbol
IGF2
  Official Full Name
insulin like growth factor 2
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:2129112 - End:2141238)
  Strand
-
  Uniprot Entry
P01344 
  ENSG ID
ENSG00000167244 
  Dnmivd Disease
KIRC 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Riboflavin (B2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
RIboflavin (B2) has been shown to increase overall methylation at IGF2 compared with placebo.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host IGF2 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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