Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00967)
  Official Symbol
AIDA
  Official Full Name
axin interactor, dorsalization associated
  Synonym
C1orf80;FLJ12806
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:222668013 - End:222713210)
  Strand
-
  Uniprot Entry
Q96BJ3 
  ENSG ID
ENSG00000186063 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C73: Malignant neoplasms of ovary High grade serous ovarian cancer (HGSOC) [Malignant neoplasms of ovary]
            Detailed Information Disease Link click to show the detail information of this Disease
         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
            Detailed Information Disease Link click to show the detail information of this Disease
         5B81: Obesity Obesity [Obesity]
            Detailed Information Disease Link click to show the detail information of this Disease
         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
            Detailed Information Disease Link click to show the detail information of this Disease
         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
            Detailed Information Disease Link click to show the detail information of this Disease
         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
            Detailed Information Disease Link click to show the detail information of this Disease
         SD86: Dementia disorder Dementia [Dementia disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate AIDA CpG site in breast cancer cells.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host AIDA (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.