Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00535)
  Official Symbol
DRAM2
  Official Full Name
DNA damage regulated autophagy modulator 2
  Synonym
MGC54289;PRO180;RP5-1180E21.1;TMEM77;WWFQ154
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:111117333 - End:111140216)
  Strand
-
  Uniprot Entry
A0A024R0B7 
  ENSG ID
ENSG00000156171 
  Dnmivd Disease
BRCA 
    Disease Relevance (Click to Show/Hide)
         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         6B01: Panic disorder Panic Disorder [Panic disorder]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate DRAM2 CpG site in breast cancer cells.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host DRAM2 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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