Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12507)
Official Symbol		ZKSCAN4
Official Full Name		Zinc Finger With KRAB And SCAN Domains 4
Synonym		Zinc Finger Protein 307;Zinc Finger With KRAB And SCAN Domains 4;Zinc Finger Protein 427;P373c6.1;P1P373C6;ZSCAN36;P373c6.1 (Novel C2H2 Type Zinc Finger Protein);EC 4.2.1.52;EC 2.1.1.43;ZNF427
Molecule Type		Protein coding
Position On Chromosome		chr6(Start:28241697 - End:28259258)
Strand		-
Uniprot Entry		Q969J2
ENSG ID		ENSG00000187626
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
LD2C: Overgrowth syndromes		Sotos syndrome(SS) [Overgrowth syndromes]
Detailed Information		Disease Link click to show the detail information of this Disease
SE30: Developmental delay disorder		CHARGE and Kabuki syndromes [Developmental delay disorder]
Detailed Information		Disease Link click to show the detail information of this Disease
XH4XG8: Chronic myeloid leukaemia		Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate ZKSCAN4 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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