Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12474)
Official Symbol		TSR1
Official Full Name		TSR1 Ribosome Maturation Factor
Synonym		TSR1 Ribosome Maturation Factor;Pre-RRNA-Processing Protein TSR1 Homolog;FLJ10534;TSR1, 20S RRNA Accumulation, Homolog (Yeast);TSR1, Ribosome Maturation Factor;KIAA1401
Molecule Type		Protein coding
Position On Chromosome		chr17(Start:2322396 - End:2336657)
Strand		-
Uniprot Entry		Q2NL82
ENSG ID		ENSG00000167721
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate TSR1 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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