Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12424)
  Official Symbol
SUMO1
  Official Full Name
Small Ubiquitin Like Modifier 1
  Synonym
Small Ubiquitin Like Modifier 1;SMT3H3;SMT3C;GMP1;SUMO-1;OFC10;PIC1;UBL1;Ubiquitin-Homology Domain Protein PIC1;SMT3 Suppressor Of Mif Two 3 Homolog 1 (Yeast);SMT3 Suppressor Of Mif Two 3 Homolog 1;Ubiquitin-Like 1 (Sentrin);GAP Modifying Protein 1;SENP2;Smt3C
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:202206171 - End:202238599)
  Strand
-
  Uniprot Entry
P63165 
  ENSG ID
ENSG00000116030 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XN3DY: Helicobacter pylori Helicobacter pylori infection [Helicobacter pylori]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate SUMO1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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