Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12422)
  Official Symbol
STT3A
  Official Full Name
STT3 Oligosaccharyltransferase Complex Catalytic Subunit A
  Synonym
STT3 Oligosaccharyltransferase Complex Catalytic Subunit A;STT3-A;Integral Membrane Protein 1;ITM1;Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3A;Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3A;STT3A, Catalytic Subunit Of The Oligosaccharyltransferase Complex;Dolichyl-Diphosphooligosaccharide Protein Glycotransferase 2 3Oligosaccharyl Transferase Subunit STT3A;Transmembrane Protein TMC;EC 2.4.99.18;EC 2.4.1.119;CDG1WAD;CDG1WAR
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:125591712 - End:125625215)
  Strand
+
  Uniprot Entry
P46977 
  ENSG ID
ENSG00000134910 
    Disease Relevance (Click to Show/Hide)
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate STT3A CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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