Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12415)
  Official Symbol
U2SURP
  Official Full Name
U2 SnRNP Associated SURP Domain Containing
  Synonym
U2 SnRNP Associated SURP Domain Containing;FSAPa;SR140;U2 SnRNP-Associated SURP Motif-Containing Protein;Functional Spliceosome-Associated Protein A;Ser/Arg-Rich Domain Protein, 140 KDa;U2-Associated SR140 Protein;U2 Associated SR140 Protein;U2 SnRNP-Associated SURP Domain Containing
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:142964497 - End:143060725)
  Strand
+
  Uniprot Entry
O15042 
  ENSG ID
ENSG00000163714 
    Disease Relevance (Click to Show/Hide)
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate SR140 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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