Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12389)
  Official Symbol
SFRS2
  Official Full Name
Serine And Arginine Rich Splicing Factor 2
  Synonym
Serine And Arginine Rich Splicing Factor 2;SC-35;Splicing Factor, Arginine/Serine-Rich 2;Serine/Arginine-Rich Splicing Factor 2;SFRS2A;PR264;Splicing Component, 35 KDa;SFRS2;SRp30b;Protein PR264
  Molecule Type
Protein coding
  Position On Chromosome
chr17(Start:76734115 - End:76737411)
  Strand
-
  Uniprot Entry
Q01130 
  ENSG ID
ENSG00000161547 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypomethylateSFRS2 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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