Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12383)
  Official Symbol
SEPSECS
  Official Full Name
Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase
  Synonym
Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase;O-Phosphoseryl-TRNA(Sec) Selenium Transferase;SLA;SLA-P35;SLA/LP;Soluble Liver Antigen/Liver Pancreas Antigen;TRNA(Ser/Sec)-Associated Antigenic Protein;UGA Suppressor TRNA-Associated Protein;UGA Suppressor TRNA-Associated Protein;EC 2.9.1.N1;EC 2.9.1.2;SepSecS;TRNP48
  Molecule Type
Protein coding
  Position On Chromosome
chr4(Start:25120014 - End:25160550)
  Strand
-
  Uniprot Entry
Q9HD40 
  ENSG ID
ENSG00000109618 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         9B75: Macular disorders Age-related macular degeneration (AMD) [Macular disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate SEPSECS CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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