Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12370)
  Official Symbol
RPL7L1
  Official Full Name
Ribosomal Protein L7 Like 1
  Synonym
Ribosomal Protein L7 Like 1;DJ475N16.4;Large Ribosomal Subunit Protein UL30-Like 1;60S Ribosomal Protein L7-Like 1;Ribosomal Protein L7-Like 1
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:42879616 - End:42889925)
  Strand
+
  Uniprot Entry
Q6DKI1 
  ENSG ID
ENSG00000146223 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate RPL7L1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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