Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12355)
  Official Symbol
RCHY1
  Official Full Name
Ring Finger And CHY Zinc Finger Domain Containing 1
  Synonym
Ring Finger And CHY Zinc Finger Domain Containing 1;RNF199;ZNF363;CHIMP;ARNIP;PRO1996;PIRH2;ZCHY;RING Finger And CHY Zinc Finger Domain-Containing Protein 1;Zinc Finger Protein 363;Zinc Finger, CHY-Type;DKFZp586C1620;Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase;Androgen Receptor N-Terminal-Interacting Protein;CH-Rich Interacting Match With PLAG1;CH-Rich-Interacting Match With PLAG1
  Molecule Type
Protein coding
  Position On Chromosome
chr4(Start:75479033 - End:75514764)
  Strand
-
  Uniprot Entry
Q96PM5 
  ENSG ID
ENSG00000163743 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate RCHY1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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