Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12338)
  Official Symbol
PSMA3
  Official Full Name
Proteasome 20S Subunit Alpha 3
  Synonym
Proteasome 20S Subunit Alpha 3;Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3;HC8;Multicatalytic Endopeptidase Complex Subunit C8;Proteasome Subunit Alpha Type-3;Proteasome Subunit Alpha 3;Proteasome Subunit C8;EC 3.4.25.1;PSC3;PSC8
  Molecule Type
Protein coding
  Position On Chromosome
chr14(Start:58244843 - End:58272012)
  Strand
+
  Uniprot Entry
P25788 
  ENSG ID
ENSG00000100567 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PSMA3 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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