Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12330)
  Official Symbol
PPP3CB
  Official Full Name
Protein Phosphatase 3 Catalytic Subunit Beta
  Synonym
CALNA2;CNA2;PP2Bbeta;CALNB;Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Beta Isoform;Isoform (Calcineurin A Beta);Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform;Protein Phosphatase 2B, Catalytic Subunit, Beta Isoform;Calmodulin-Dependent Calcineurin A Subunit Beta Isoform;Protein Phosphatase From PCR Fragment H32;Calcineurin A2
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:73436433 - End:73496024)
  Strand
-
  Uniprot Entry
P16298 
  ENSG ID
ENSG00000107758 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PPP3CB CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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