Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12319)
  Official Symbol
PLA2G1B
  Official Full Name
Phospholipase A2 Group IB
  Synonym
Phospholipase A2 Group IB;PLA2A;PPLA2;PLA2;Phosphatidylcholine 2-Acylhydrolase 1B;Phospholipase A2, Group IB (Pancreas);EC 3.1.1.4;Group IB Phospholipase A2;Phospholipase A2
  Molecule Type
Protein coding
  Position On Chromosome
chr12(Start:120322115 - End:120327779)
  Strand
-
  Uniprot Entry
P04054 
  ENSG ID
ENSG00000170890 
    Disease Relevance (Click to Show/Hide)
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PLA2G1B CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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