Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12317)
  Official Symbol
PIGA
  Official Full Name
Phosphatidylinositol Glycan Anchor Biosynthesis Class A
  Synonym
Phosphatidylinositol Glycan Anchor Biosynthesis Class A;Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A;EC 2.4.1.198;PIG-A;Phosphatidylinositol Glycan, Class A (Paroxysmal Nocturnal;GPI3;GlcNAc-PI Synthesis Protein;GPI Anchor Biosynthesis;Phosphatidylinositol N-Acetylglucosaminyltransferase
  Molecule Type
Protein coding
  Position On Chromosome
chrX(Start:15319451 - End:15335554)
  Strand
-
  Uniprot Entry
P37287 
  ENSG ID
ENSG00000165195 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Sex chromosome anomalies X-chromosome inactivation (XCI) [Sex chromosome anomalies]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PIGA CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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