Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12280)
Official Symbol		OGFOD1
Official Full Name		2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1
Synonym		2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1;KIAA1612;TAP1;2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 1;Termination And Polyadenylation 1 Homolog;Prolyl 3-Hydroxylase OGFOD1;TPA1, Termination And Polyadenylation 1, Homolog (S. Cerevisiae);2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1;TPA1, Termination And Polyadenylation 1, Homolog;EC 1.14.11;EC 1.14.11
Molecule Type		Protein coding
Position On Chromosome		chr16(Start:56451521 - End:56479104)
Strand		+
Uniprot Entry		Q8N543
ENSG ID		ENSG00000087263

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate OGFOD1 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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