Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12252)
  Official Symbol
NDFIP2
  Official Full Name
Nedd4 Family Interacting Protein 2
  Synonym
Nedd4 Family Interacting Protein 2;KIAA1165;Putative MAPK-Activating Protein PM04/PM05/PM06/PM07;Putative NF-Kappa-B-Activating Protein 413;NEDD4 Family-Interacting Protein 2MAPK-Activating Protein PM04 PM05 PM06 PM07;NF-Kappa-B-Activating Protein 413;N4wbp5a
  Molecule Type
Protein coding
  Position On Chromosome
chr13(Start:79481124 - End:79556077)
  Strand
+
  Uniprot Entry
Q9NV92 
  ENSG ID
ENSG00000102471 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate NDFIP2 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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