Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12217)
  Official Symbol
MIR17HG
  Official Full Name
MiR-17-92a-1 Cluster Host Gene
  Synonym
MiR-17-92a-1 Cluster Host Gene;MIRH1;NCRNA00048;MiR-17-92;LINC00048;C13orf25;MIRHG1;MIHG1;Long Intergenic Non-Protein Coding RNA 48;MicroRNA Host Gene 1 (Non-Protein Coding);MIR17 Host Gene (Non-Protein Coding);FLJ14178;HSALNG0098601;NONHSAG013949.2;Chromosome 13 Open Reading Frame 25;MicroRNA Host Gene (Non-Protein Coding) 1
  Molecule Type
RNA Gene
  Position On Chromosome
chr13(Start:91347686 - End:91397097)
  Strand
+
  Uniprot Entry
Q75NE6 
  ENSG ID
ENSG00000215417 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate MIR17HG CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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