Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12172)
Official Symbol		LIAS
Official Full Name		Lipoic Acid Synthetase
Synonym		Lipoyl Synthase, Mitochondrial;Lipoic Acid Synthetase;LAS;Lipoate Synthase;EC 2.8.1.8;Lip-Syn;PDHLD;LIP1;Lipoic Acid Synthase
Molecule Type		Protein coding
Position On Chromosome		chr4(Start:39459004 - End:39485109)
Strand		+
Uniprot Entry		O43766
ENSG ID		ENSG00000121897
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate LIAS CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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