Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12122)
  Official Symbol
H4C3
  Official Full Name
H4 Clustered Histone 3
  Synonym
H4 Clustered Histone 3;DJ221C16.1;H4/G;Histone Cluster 1 H4 Family Member C;H4FGHistone 1, H4c;H4C8;H4FA
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:26103933 - End:26104337)
  Strand
+
  Uniprot Entry
P62805 
  ENSG ID
ENSG00000197061 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate HIST1H4C CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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