Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12117)
  Official Symbol
H2BC11
  Official Full Name
H2B Clustered Histone 11
  Synonym
H2B Clustered Histone 11;H2B/R;HIST1H2BJ;H2BFR;Histone Cluster 1 H2B Family Member J;H2B Histone Family, Member R;Histone H2B.1H2BJ
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:27125897 - End:27132795)
  Strand
-
  Uniprot Entry
P06899 
  ENSG ID
ENSG00000124635 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate HIST1H2BJ CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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