Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12114)
  Official Symbol
H1-3
  Official Full Name
H1.3 Linker Histone, Cluster Member
  Synonym
HIST1H1D;H1.3 Linker Histone, Cluster Member;H1F3;Histone Cluster 1 H1 Family Member D;Histone H1.3;H1 Histone Family, Member 3
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:26234212 - End:26234987)
  Strand
-
  Uniprot Entry
P16402 
  ENSG ID
ENSG00000124575 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate HIST1H1D CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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