Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12082)
  Official Symbol
GLRX5
  Official Full Name
Glutaredoxin 5
  Synonym
Glutaredoxin 5;C14orf87;PR01238;GRX5;Glutaredoxin-Related Protein 5, Mitochondrial;Monothiol Glutaredoxin-5;Epididymis Secretory Sperm Binding Protein;PRO1238
  Molecule Type
Protein coding
  Position On Chromosome
chr14(Start:95533503 - End:95544724)
  Strand
+
  Uniprot Entry
Q86SX6 
  ENSG ID
ENSG00000182512 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate GLRX5 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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