Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12073)
Official Symbol		GABRE
Official Full Name		Gamma-Aminobutyric Acid Type A Receptor Subunit Epsilon
Synonym		Gamma-Aminobutyric Acid (GABA) A Receptor, Epsilon;Gamma-Aminobutyric Acid Type A Receptor Subunit Epsilon;Gamma-Aminobutyric Acid Receptor Subunit EpsilonGABA(A) Receptor, Epsilon;Gamma-Aminobutyric Acid Type A Receptor Epsilon Subunit
Molecule Type		Protein coding
Position On Chromosome		chrX(Start:151953124 - End:151974692)
Strand		-
Uniprot Entry		P78334
ENSG ID		ENSG00000102287
Disease Relevance (Click to Show/Hide)
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease
XH5QN3: Nephroblastoma		Wilms tumor [Nephroblastoma]
Detailed Information		Disease Link click to show the detail information of this Disease
ZERO(Not Found): Sex chromosome anomalies		X-chromosome inactivation (XCI) [Sex chromosome anomalies]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate GABRE CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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