Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12064)
Official Symbol		FKBP3
Official Full Name		FKBP Prolyl Isomerase 3
Synonym		FKBP Prolyl Isomerase 3;FKBP25;Peptidyl-Prolyl Cis-Trans Isomerase FKBP3;Rapamycin-Selective 25 KDa Immunophilin;FK506 Binding Protein 3, 25kDa;25 KDa FK506-Binding Protein;FK506-Binding Protein 3;FK506-Binding Protein 25, T-Cell
Molecule Type		Protein coding
Position On Chromosome		chr14(Start:45115292 - End:45135319)
Strand		-
Uniprot Entry		Q00688
ENSG ID		ENSG00000100442
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate FKBP3 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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