Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12056)
  Official Symbol
FARSB
  Official Full Name
Phenylalanyl-TRNA Synthetase Subunit Beta
  Synonym
Phenylalanyl-TRNA Synthetase Subunit Beta;FARSLB;FRSB;PheHB;Phenylalanyl-TRNA Synthetase-Like, Beta Subunit;EC 6.1.1;HSPC173;NEDBLLA;RILDBC1;RILDBC
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:222566899 - End:222656092)
  Strand
-
  Uniprot Entry
Q9NSD9 
  ENSG ID
ENSG00000116120 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate FARSB CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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