Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12038)
  Official Symbol
EIF3B
  Official Full Name
Eukaryotic Translation Initiation Factor 3 Subunit B
  Synonym
Eukaryotic Translation Initiation Factor 3 Subunit B;EIF3S9;PRT1;Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa;Eukaryotic Translation Initiation Factor 3 Subunit 9;Protein Synthesis 1;Prt1 Homolog;Eukaryotic Translation Initiation Factor 3, Subunit;Eukaryotic Translation Initiation Factor 3, Subunit B;EIF3-P110;EIF3 P110
  Molecule Type
Protein coding
  Position On Chromosome
chr7(Start:2354086 - End:2380745)
  Strand
+
  Uniprot Entry
P55884 
  ENSG ID
ENSG00000106263 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate EIF3B CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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