Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12031)
  Official Symbol
DNAJA2
  Official Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member A2
  Synonym
HIRIP4;DnaJ Heat Shock Protein Family (Hsp40) Member A2;CPR3;DNAJ;Cell Cycle Progression Restoration Gene 3 Protein;DnaJ (Hsp40) Homolog, Subfamily A, Member 2;DnaJ Homolog Subfamily A Member 2;Renal Carcinoma Antigen NY-REN-14;PRO3015
  Molecule Type
Protein coding
  Position On Chromosome
chr16(Start:46955362 - End:46973674)
  Strand
-
  Uniprot Entry
O60884 
  ENSG ID
ENSG00000069345 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate DNAJA2 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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