Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12015)
  Official Symbol
DCLRE1B
  Official Full Name
DNA Cross-Link Repair 1B
  Synonym
DNA Cross-Link Repair 1B;SNM1B;APOLLO;DNA Cross-Link Repair 1B (PSO2 Homolog, S. Cerevisiae);Beta-Lactamase DCLRE1B;5' Exonuclease Apollo;SNM1 Homolog B;FLJ12810;PSO2 Homolog (S. Cerevisiae);PSO2 Homolog;DNA Cross-Link Repair 1B Protein
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:113904619 - End:113914086)
  Strand
+
  Uniprot Entry
Q9H816 
  ENSG ID
ENSG00000118655 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate DCLRE1B CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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