Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12001)
  Official Symbol
COX6A1
  Official Full Name
Cytochrome C Oxidase Subunit 6A1
  Synonym
COX6AL;Cytochrome C Oxidase Subunit 6A1;Cytochrome C Oxidase Subunit 6A1, Mitochondrial;Cytochrome C Oxidase Subunit VIa Polypeptide 1;CMTRID;Cytochrome C Oxidase Subunit VIa Homolog;COX6A;Cytochrome C Oxidase Subunit VIA-Liver
  Molecule Type
Protein coding
  Position On Chromosome
chr12(Start:120438090 - End:120440737)
  Strand
+
  Uniprot Entry
P12074 
  ENSG ID
ENSG00000111775 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate COX6A1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.