Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11973)
  Official Symbol
CCT3
  Official Full Name
Chaperonin Containing TCP1 Subunit 3
  Synonym
Chaperonin Containing TCP1, Subunit 3 (Gamma);T-Complex Protein 1 Subunit Gamma;Chaperonin Containing TCP1 Subunit 3;CCT-Gamma;TCP-1-Gamma;PIG48;T-Complex Protein 1, Gamma Subunit
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:156308968 - End:156308968)
  Strand
-
  Uniprot Entry
P49368 
  ENSG ID
ENSG00000163468 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate CCT3 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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