Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11939)
Official Symbol		TYW5
Official Full Name		TRNA-YW Synthesizing Protein 5
Synonym		TRNA-YW Synthesizing Protein 5;C2orf60;TRNA(Phe) (7-(3-Amino-3-Carboxypropyl)Wyosine(37)-C(2))-Hydroxylase;TRNA Wybutosine-Synthesizing Protein 5;FLJ37953;Chromosome 2 Open Reading Frame 60;JmjC Domain-Containing Protein C2orf60;TRNA YW-Synthesizing Enzyme 5
Molecule Type		Protein coding
Position On Chromosome		chr2(Start:199928913 - End:199955736)
Strand		-
Uniprot Entry		A2RUC4
ENSG ID		ENSG00000162971

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate C2orf60 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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