Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11929)
Official Symbol		METTL18
Official Full Name		Methyltransferase Like 18
Synonym		Methyltransferase Like 18;AsTP2;C1orf156;HPM1;Histidine Protein Methyltransferase 1 Homolog;Methyltransferase-Like Protein 18;Histidine Protein Methyltransferase 1;Chromosome 1 Open Reading Frame 156;ASTP2;EC 2.1.1.85
Molecule Type		Protein coding
Position On Chromosome		chr1(Start:169792524 - End:169794963)
Strand		-
Uniprot Entry		O95568
ENSG ID		ENSG00000171806
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate C1orf156 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.