Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11892)
  Official Symbol
B4GALNT4
  Official Full Name
Beta-1,4-N-Acetyl-Galactosaminyltransferase 4
  Synonym
Beta-1,4-N-Acetyl-Galactosaminyltransferase 4;NGalNAc-T1;N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N-Acetylgalactosaminyltransferase 1;N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N- Acetylgalactosaminyltransferase;Beta-1,4-N-Acetylgalactosaminyltransferase IV;Beta4GalNAc-T4;Beta-1,4-N-Acetyl-Galactosaminyl Transferase 4;Beta1,4-N-Acetylgalactosaminyltransferases IV
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:369499 - End:382117)
  Strand
+
  Uniprot Entry
Q76KP1 
  ENSG ID
ENSG00000182272 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2FZERO(Not Found)0: Toxic or drug-related embryofetopathies Fetal alcohol spectrum disorder (FASD) [Toxic or drug-related embryofetopathies]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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         ZERO(Not Found): Glomerular diseases IgA nephropathy [Glomerular diseases]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate B4GALNT4 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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