Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11846)
  Official Symbol
RBFOX1
  Official Full Name
RNA Binding Fox-1 Homolog 1
  Synonym
HRNBP1;FOX-1;RNA Binding Protein, Fox-1 Homolog 1;Hexaribonucleotide-Binding Protein 1;RNA Binding Protein Fox-1 Homolog 1;Fox-1 Homolog A;FOX1;RNA Binding Protein, Fox-1 Homolog (C. Elegans) 1;Hexaribonucleotide Binding Protein 1;Fox-1-Like RNA-Binding Protein 1;Ataxin-2-Binding Protein 1;2BP1;A2BP
  Molecule Type
Protein coding
  Position On Chromosome
chr16(Start:5239752 - End:7713343)
  Strand
+
  Uniprot Entry
Q9NWB1 
  ENSG ID
ENSG00000078328 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Kagami-Ogata syndrome KOS14: Kagami-Ogata syndrome [Kagami-Ogata syndrome]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate A2BP1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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