Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10490)
  Official Symbol
FAH
  Official Full Name
fumarylacetoacetate hydrolase
  Molecule Type
Protein coding
  Position On Chromosome
chr15(Start:80152490 - End:80186946)
  Strand
+
  Uniprot Entry
P16930 
  ENSG ID
ENSG00000103876 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate FAH CpG site in breast cancer cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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