Details of Epigenetic Molecule(EM)
| General Information of EM (ID: EM07216) | |||||||
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| Official Symbol |
LIN52
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| Official Full Name |
lin-52 DREAM MuvB core complex component
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| Synonym |
C14orf46
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| Molecule Type |
Protein coding
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| Position On Chromosome |
chr14(Start:74084796 - End:74201235)
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| Strand |
+
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| Uniprot Entry | |||||||
| ENSG ID | |||||||
| Dnmivd Disease | |||||||
| Disease Relevance (Click to Show/Hide) | |||||||
| 2A00: Primary neoplasms of brain | Glioma [Primary neoplasms of brain] | ||||||
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| 2A01: Primary neoplasms of meninges | Meningioma [Primary neoplasms of meninges] | ||||||
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| 2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx | Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx] | ||||||
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| 2B70: Malignant neoplasms of oesophagus | Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus] | ||||||
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| 2B90: Malignant neoplasms of colon | Colorectal cancer [Malignant neoplasms of colon] | ||||||
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| 2C25: Malignant neoplasms of bronchus or lung | Lung cancer [Malignant neoplasms of bronchus or lung] | ||||||
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| 2C60: Carcinoma of breast | Breast cancer [Carcinoma of breast] | ||||||
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| 4A40: Lupus erythematosus | Systemic lupus erythematosus (SLE) [Lupus erythematosus] | ||||||
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| 6A00: Disorders of intellectual development | Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development] | ||||||
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| 6E8Z: Mental, behavioural or neurodevelopmental disorders | Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders] | ||||||
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| 8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
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| 8A40: Multiple sclerosis | Multiple sclerosis [Multiple sclerosis] | ||||||
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| 9A01: Infectious disorders of eyelid | Human eye and its diseases [Infectious disorders of eyelid] | ||||||
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| DB92: Non-alcoholic fatty liver disease | Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease] | ||||||
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| DD70: Crohn disease | Crohn's disease [Crohn disease] | ||||||
| Detailed Information |
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| GA10: Endometriosis | Endometriosis [Endometriosis] | ||||||
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| LD44: Deletions of the autosomes | Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes] | ||||||
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| SD86: Dementia disorder | Dementia [Dementia disorder] | ||||||
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| SE30: Developmental delay disorder | CHARGE and Kabuki syndromes [Developmental delay disorder] | ||||||
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| XB8M: Congenital | Melanoma [Congenital] | ||||||
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| XH1E13: Germinoma | Germinoma [Germinoma] | ||||||
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| XH1XF3: Osteosarcoma | Osteosarcoma [Osteosarcoma] | ||||||
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| XH3DV3: Adenoma | Adenoma [Adenoma] | ||||||
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| XH4S92: Leukaemia | Leukemia [Leukaemia] | ||||||
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| XH5QN3: Nephroblastoma | Wilms tumor [Nephroblastoma] | ||||||
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| XH7F82: Glioblastoma | Glioblastoma [Glioblastoma] | ||||||
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| XH7PW5: Lymphocytic leukaemia | Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia] | ||||||
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| XH85Z0: Neuroblastoma | Neuroblastoma [Neuroblastoma] | ||||||
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| XH8AA5: Acute myeloid leukaemia | Acute myeloid leukemia (AML) [Acute myeloid leukaemia] | ||||||
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| XH8P29: Medulloblastoma | Medulloblastoma [Medulloblastoma] | ||||||
| Detailed Information |
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| XH8SH6: CNS embryonal tumour | Primitive neuroectodermal tumors [CNS embryonal tumour] | ||||||
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| XH98Z3: Schwannoma | Schwannoma [Schwannoma] | ||||||
| Detailed Information |
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| XH9HQ1: Gastrointestinal stromal tumour | Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour] | ||||||
| Detailed Information |
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| XN487: Human immunodeficiency virus | Human immunodeficiency virus (HIV) [Human immunodeficiency virus] | ||||||
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| Protein(s) with this epigenetic modification | |||||||
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| Protein Name: Rv2966c | |||||||
| Detailed Information |
Pro Info
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[1] | |||||
| Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host LIN52 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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| References | |||||
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| 1 | Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006. | ||||
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