Details of Epigenetic Molecule(EM)
| General Information of EM (ID: EM05527) | |||||||
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| Official Symbol |
KIFBP
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| Official Full Name |
kinesin family binding protein
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| Synonym |
DKFZP586B0923;KBP;KIAA1279;KIF1BP;TTC20
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| Molecule Type |
Protein coding
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| Position On Chromosome |
chr10(Start:68988803 - End:69043544)
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| Strand |
+
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| Uniprot Entry | |||||||
| ENSG ID | |||||||
| Disease Relevance (Click to Show/Hide) | |||||||
| 1F84: Opisthorchiasis | Opisthorchis viverrini [Opisthorchiasis] | ||||||
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| 2A00: Primary neoplasms of brain | Glioma [Primary neoplasms of brain] | ||||||
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| 2A01: Primary neoplasms of meninges | Meningioma [Primary neoplasms of meninges] | ||||||
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| 2A90: Mature T-cell lymphoma, specified types, nodal or systemic | Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic] | ||||||
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| 2B6B: Malignant neoplasms of nasopharynx | Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx] | ||||||
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| 2B70: Malignant neoplasms of oesophagus | Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus] | ||||||
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| 2B70: Malignant neoplasms of oesophagus | Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus] | ||||||
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| 2B72: Malignant neoplasms of stomach | Gastric cancer [Malignant neoplasms of stomach] | ||||||
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| 2B90: Malignant neoplasms of colon | Colon adenocarcinoma [Malignant neoplasms of colon] | ||||||
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| 2B90: Malignant neoplasms of colon | Colorectal cancer [Malignant neoplasms of colon] | ||||||
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| 2C10: Malignant neoplasm of pancreas | Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas] | ||||||
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| 2C12: Malignant neoplasms of liver or intrahepatic bile ducts | Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts] | ||||||
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| 2C25: Malignant neoplasms of bronchus or lung | Lung adenocarcinoma [Malignant neoplasms of bronchus or lung] | ||||||
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| 2C25: Malignant neoplasms of bronchus or lung | Lung cancer [Malignant neoplasms of bronchus or lung] | ||||||
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| 2C25: Malignant neoplasms of bronchus or lung | Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung] | ||||||
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| 2C60: Carcinoma of breast | Breast cancer [Carcinoma of breast] | ||||||
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| 2C73: Malignant neoplasms of ovary | Ovarian serous adenocarcinoma (OSA) [Malignant neoplasms of ovary] | ||||||
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| 2D10: Malignant neoplasms of thyroid gland | Thyroid tumors [Malignant neoplasms of thyroid gland] | ||||||
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| 2E66: Carcinoma in situ of cervix uteri | Cervical squamous cell carcinoma [Carcinoma in situ of cervix uteri] | ||||||
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| 4A20: Acquired immunodeficiencies | Immunodeficiency [Acquired immunodeficiencies] | ||||||
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| 4A40: Lupus erythematosus | Systemic lupus erythematosus (SLE) [Lupus erythematosus] | ||||||
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| 4A43: Overlap or undifferentiated nonorgan specific systemic autoimmune disease | Sjgren's Syndrome [Overlap or undifferentiated nonorgan specific systemic autoimmune disease] | ||||||
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| 5B81: Obesity | Obesity [Obesity] | ||||||
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| 6A00: Disorders of intellectual development | Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development] | ||||||
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| 6A02: Autism spectrum disorder | Autism [Autism spectrum disorder] | ||||||
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| 6A20: Schizophrenia | Schizophrenia [Schizophrenia] | ||||||
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| 6E8Z: Mental, behavioural or neurodevelopmental disorders | Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders] | ||||||
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| 8A00: Parkinsonism | Parkinson's disease (PD) [Parkinsonism] | ||||||
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| 8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
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| 8A40: Multiple sclerosis | Multiple sclerosis [Multiple sclerosis] | ||||||
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| 8E49: Postviral fatigue syndrome | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [Postviral fatigue syndrome] | ||||||
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| 9A01: Infectious disorders of eyelid | Human eye and its diseases [Infectious disorders of eyelid] | ||||||
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| BD40: Atherosclerotic chronic arterial occlusive disease | Atherosclerosis [Atherosclerotic chronic arterial occlusive disease] | ||||||
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| CA22: Chronic obstructive pulmonary disease | Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease] | ||||||
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| CB03: Idiopathic interstitial pneumonitis | Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis] | ||||||
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| DD70: Crohn disease | Crohn's disease [Crohn disease] | ||||||
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| FA20: Rheumatoid arthritis | Rheumatoid arthritis [Rheumatoid arthritis] | ||||||
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| FA21: Psoriatic arthritis | Psoriatic [Psoriatic arthritis] | ||||||
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| GA10: Endometriosis | Endometriosis [Endometriosis] | ||||||
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| JA24: Pre-eclampsia | Preeclampsia (PE) [Pre-eclampsia] | ||||||
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| LA02: Spina bifida | Neural tube defects (NTDs) [Spina bifida] | ||||||
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| LD2C: Overgrowth syndromes | Sotos syndrome(SS) [Overgrowth syndromes] | ||||||
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| MG30: Chronic pain | Fibromyalgia [Chronic pain] | ||||||
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| SD86: Dementia disorder | Dementia [Dementia disorder] | ||||||
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| SE30: Developmental delay disorder | CHARGE and Kabuki syndromes [Developmental delay disorder] | ||||||
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| XB8M: Congenital | Melanoma [Congenital] | ||||||
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| XH0945: Squamous cell carcinoma | Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma] | ||||||
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| XH1E13: Germinoma | Germinoma [Germinoma] | ||||||
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| XH1ND9: Papillary carcinoma of thyroid | Papillary thyroid carcinoma [Papillary carcinoma of thyroid] | ||||||
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| XH1XF3: Osteosarcoma | Osteosarcoma [Osteosarcoma] | ||||||
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| XH3DV3: Adenoma | Adenoma [Adenoma] | ||||||
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| XH4546: Signet ring cell carcinoma | Signet ring cell colorectal cancer [Signet ring cell carcinoma] | ||||||
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| XH46F1: Clear cell renal cell carcinoma | Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma] | ||||||
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| XH5QN3: Nephroblastoma | Wilms tumor [Nephroblastoma] | ||||||
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| XH68V1: Liver cell adenoma | Hepatocellular adenoma [Liver cell adenoma] | ||||||
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| XH6PH6: Astrocytoma | Astrocytoma [Astrocytoma] | ||||||
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| XH7F82: Glioblastoma | Glioblastoma [Glioblastoma] | ||||||
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| XH7PW5: Lymphocytic leukaemia | Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia] | ||||||
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| XH7ZQ4: Atypical teratoid/rhabdoid tumour | Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour] | ||||||
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| XH85Z0: Neuroblastoma | Neuroblastoma [Neuroblastoma] | ||||||
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| XH8AA5: Acute myeloid leukaemia | Acute myeloid leukemia (AML) [Acute myeloid leukaemia] | ||||||
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| XH8P29: Medulloblastoma | Medulloblastoma [Medulloblastoma] | ||||||
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| XH8P29: Medulloblastoma | Primary medulloblastoma [Medulloblastoma] | ||||||
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| XH8SH6: CNS embryonal tumour | Primitive neuroectodermal tumors [CNS embryonal tumour] | ||||||
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| XH9HQ1: Gastrointestinal stromal tumour | Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour] | ||||||
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| XN487: Human immunodeficiency virus | Human immunodeficiency virus (HIV) [Human immunodeficiency virus] | ||||||
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| ZERO(Not Found): Acute mania and inflammatory | Acute mania and inflammatory [Acute mania and inflammatory] | ||||||
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| ZERO(Not Found): Constitutional MLH1 epimutations | Constitutional MLH1 epimutations [Constitutional MLH1 epimutations] | ||||||
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| Protein(s) with this epigenetic modification | |||||||
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| Protein Name: Rv2966c | |||||||
| Detailed Information |
Pro Info
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[1] | |||||
| Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host KIAA1279 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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| References | |||||
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| 1 | Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006. | ||||
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